Following a TV program on the French-German public network ARTE that denied the proven link between cholesterol levels and CVD, the potential effects of such disinformation are considered.
The method is an adaptation of the Friedwald formula that incorporates a patient-specific TG:VLDL-ratio. Added accuracy is largest in those with LDL-c <70 mg/dL, without added expense.
In a large population-based study, high TG levels identified individuals at high CVD risk, who would not be definite eligible for statin treatment according to the 2016 ESC/EAS guidelines.
In a meta-analysis of 13 observational studies, statin use was associated with a modest reduction in the risk of developing Parkinson’s Disease compared with not using statins.
Men with LDL-c levels ≥190 mg/dL without atherosclerotic CVD, have a 2-fold higher risk of major CV events than would be predicted with a risk calculator.
These data underscore the importance of prospectively monitoring lipid parameters in all patients starting psychotropic treatment, as these drugs may induce or exacerbate dyslipidemia.
Based on data of the large Dutch Lifelines cohort, reference values have been developed for lipid parameters.
Skipping breakfast was associated with a higher risk of non-coronary and generalized atherosclerosis in a sample of asymptomatic individuals in thee prospective PESA study.
In the IMPROVE-IT study, the addition of ezetimibe to simvastatin in stabilized post-ACS patients reduced the frequency of ischemic stroke, particularly in patients with a history of prior stroke.
Post-AMI patients who are adherent to ACE inhibitors/ARBs and statins, but not to beta-blockers, had a similar mortality risk compared with those adherent to all 3 therapies.
In children and adolescents with HoFH, rosuvastatin 20 mg alone or in combination with ezetimibe and/or apheresis led to an effective LDL-C reduction, and was well tolerated.
ESC 2017 FOURIER trial data show that after 2.2 years of follow-up, very low LDL-c levels are still associated with further reduction of CV events, without an increase in safety events.