European Primary Care Cardiovascular Society

Striking results for weight reduction in T2DM in primary care based program

IDF 2017 - Abu Dhabi, UAE

Dec. 18, 2017 - IDF 2017 - Abu Dhabi, UAE - Prof Naveed Sattar, MD - Glasgow, UK
**IDF 2017** Prof Sattar reports on the results of the DIRECT trial evaluating the intervention with a weight management program with huge implications for clinical practice. Almost 75% of the patients in the intervention group had a weight loss >10 kg and half of the patients in this group had remission of diabetes after 1 year of the start of the trial.

IDF 2017 Prof Sattar reports on the results of the DiRECT trial evaluating a weight management program with huge implications for clinical practice. Almost half of the patients in the intervention group had remission of T2DM 1 year after the start of the trial.

Primary care-based dietary and lifestyle intervention leads to remission of T2DM

Dec. 11, 2017 - Lean MEJ et al., The Lancet 2017

The randomised DIRECT trial evaluated a practical weight management program. On average, weigh reduced by 10 kg and almost half achieved and maintained remission of T2DM at 12 months after starting the intervention.

Cognitive dysfunction in diabetic patients partly explained by hyperglycemia

Nov. 1, 2017 - Geijselaers SLC et al., Diabetes Care 2017

Differences in cognitive performance between diabetic patients and individuals with normal glucose levels can be explained by hyperglycemia and by BP-related variables, but not by insulin resistance.

Diabetic patients at high CV risk benefit from intensive BP control

Oct. 5, 2017 - Buckley LF et al., Diabetes Care 2017

In a SPRINT-eligible ACCORD-BP population, a high-risk cohort of diabetic patients, intensive BP control at a goal of <120 mmHg, reduced CVD outcomes.

Obesity without metabolic abnormalities still associated with increased CV risk

Sep. 25, 2017 - Caleyachetty R et al., J Am Coll Cardiol 2017

Individuals previously considered “metabolically healthy obese” are still at higher CV risk compared with normal weight metabolically healthy persons, according to a large UK health record dataset.

Six instead of three meals per day improves glucose control in obese people with diabetes

Sep. 16, 2017 - news

EASD 2017 Obese people with prediabetes or diabetes showed better glucose control and were less hungry when taking six meals per day than with three, at an identical level of total calories.

New NHS device to help loose weight and improve glucose regulation in obese T2DM patients

Sep. 14, 2017 - news

EASD 2017 NHS provides the new, non-surgical, reversible weight loss Endobarrier device to help patients with poorly controlled T2DM and obesity kickstart a change in lifestyle.

Causal association BMI and cardio-metabolic disease confirmed by genetic studies

July 14, 2017 - Lyall DM, et al, JAMA Cardiol 2017

In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate. 

Certain traditional Chinese medicines may help improve CV risk or even CVD

June 14, 2017 - Hao P et al., JACC 2017
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Systematic review of RCT evidence suggests that some TCM medications might improve CV risk factors and some may exert beneficial effects on ASCVD and chronic HF. Not all studies are of high methodological quality.

Risk stratification in diabetic patients can be improved by considering SBP variability

June 8, 2017 - Ohkuma T et al., Hypertension 2017

In diabetic patients, the SBP visit-to-visit variability was an independent predictor of vascular complications and death, and improved the predictive ability of traditional risk factors.

Long-term metformin seems to protect against coronary atherosclerosis in prediabetic men

June 8, 2017 - Goldberg RB et al., Circulation 2017

In a large Diabetes Prevention Program, men with prediabetes treated with metformin for an average duration of 14 years had lower coronary calcium scores compared with the placebo group.

Mendelian randomisation shows causal relation adiposity with CHD and T2DM

May 18, 2017 - Dale C, et al, Circulation, 2017

Mendelian analysis confirms a causal relationship of both central and general adiposity with the risk of CHD and T2DM, whereas central adiposity was stronger linked to ischemic stroke.