Diabetes is now considered an important risk factor for cardiovascular disease, and a complex interplay of pathogenic factors complicates management of both diseases.
IDF 2017 Prof Sattar reports on the results of the DiRECT trial evaluating a weight management program with huge implications for clinical practice. Almost half of the patients in the intervention group had remission of T2DM 1 year after the start of the trial.
The randomised DIRECT trial evaluated a practical weight management program. On average, weigh reduced by 10 kg and almost half achieved and maintained remission of T2DM at 12 months after starting the intervention.
Differences in cognitive performance between diabetic patients and individuals with normal glucose levels can be explained by hyperglycemia and by BP-related variables, but not by insulin resistance.
In a SPRINT-eligible ACCORD-BP population, a high-risk cohort of diabetic patients, intensive BP control at a goal of <120 mmHg, reduced CVD outcomes.
Individuals previously considered “metabolically healthy obese” are still at higher CV risk compared with normal weight metabolically healthy persons, according to a large UK health record dataset.
EASD 2017 Obese people with prediabetes or diabetes showed better glucose control and were less hungry when taking six meals per day than with three, at an identical level of total calories.
EASD 2017 NHS provides the new, non-surgical, reversible weight loss Endobarrier device to help patients with poorly controlled T2DM and obesity kickstart a change in lifestyle.
In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate.
Systematic review of RCT evidence suggests that some TCM medications might improve CV risk factors and some may exert beneficial effects on ASCVD and chronic HF. Not all studies are of high methodological quality.
In diabetic patients, the SBP visit-to-visit variability was an independent predictor of vascular complications and death, and improved the predictive ability of traditional risk factors.
In a large Diabetes Prevention Program, men with prediabetes treated with metformin for an average duration of 14 years had lower coronary calcium scores compared with the placebo group.
Mendelian analysis confirms a causal relationship of both central and general adiposity with the risk of CHD and T2DM, whereas central adiposity was stronger linked to ischemic stroke.