European Primary Care Cardiovascular Society

Improved prescription of therapies with multifaceted intervention in T2DM and ASCVD

News - Mar. 14, 2023

Coordinating Cardiology Clinics Randomized Trial of Interventions to Improve Outcomes (COORDINATE)-Diabetes: Primary Results

Presented at the ACC.23/WCC by: Neha Pagidipati, MD - Durham, NC, USA

Introduction and methods

A recent study showed that high-intensity statins, ACEi/ARBs and SGLT2i or GLP-1RAs are underused in clinical practice, despite proven benefits in patients with T2DM and ASCVD, and recommendations for these agents in guidelines and by medical societies. In a recent study in the US, 2.7% of patients were on all 3 groups and 37.4% were on none (Nelson et al., JAHA 2021,10(2):e016835).

The COORDINATE-Diabetes trial was an RCT with randomization at the clinic level. 43 Cardiology clinics in the US enrolling patients with T2DM and ASCVD were randomized to a multifaceted intervention or usual care. The intervention was multifaceted and based on 3 core principles: assessment of local practices and barriers, development of strategies to overcome those barrier and audit and feedback. A team of the COORDINATE-center facilitated the intervention at the local sites.

The primary outcome was the proportion of patients who had prescription of all 3 groups of recommended therapies, which included high-intensity statin, ACEi or ARB and a SGLT2i or GLP-1RA, at 12 months follow-up.

Main results


This RCT showed that a multifaceted intervention is effective in increasing the prescription of evidence-based therapies in patients with T2DM and ASCVD. The presenter - Neha Pagidipati- noted that the next step is to scale this intervention across cardiology practices to improve the quality of care for patients with T2DM and ASCVD.

- Our reporting is based on the information provided at the ACC.23/WCC -

The findings of this study were simultaneously published in JAMA Details of the intervention can be found online

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