European Primary Care Cardiovascular Society
Global CVD burden has increased in almost all regions outside high-income countries. The increase was largely due to population growth and aging. In addition, attribution of risk factors like SBP, BMI, and dietary risk increased worldwide.
Patients with HF admitted to hospital for COVID-19 had increased risk for in-hospital mortality and needed more often ICU care and intubation and mechanical ventilation compared to patients without HF.
A nationally representative cohort study of US adults showed that a higher proportion of vigorous physical activity to total physical activity (moderate to vigorous) was associated with lower all-cause mortality.
This position paper discusses the cause and consequences of endothelial injury and dysfunction in COVID-19.
In a contemporary primary prevention cohort, MI and ASCVD event rates increased with higher LDL-c and older age.
Although relative risk for MI per 1 mmol/L higher LDL-c is similar across age groups, absolute risk for MI and ASCVD per LDL categories is much higher in individuals 80-100 years compared to those <70 years.
Triglycerides and remnant-c, but not LDL-c and HDL-c, were associated with MACE in a primary prevention cohort of high CV risk subjects with high prevalence of diabetes and obesity.
Offspring of mothers with an ideal CVH score lived longer CVD free lives than children from mothers with a poor CV health pattern. The incidence rate for CVD was significantly higher among sons than daughters.
Findings of a study using real-world data from REGARDS showed that prevalence of polypharmacy, defined as ≥10 medications, is high in older patients hospitalized for HF.
A study of network approaches with clinical and pre-clinical validation showed that NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism of an age-related hypertension endotype.
An observational study showed that the absolute risk of myopathy is low in patients taking simvastatin. A myopathy risk score showed no association with other muscle symptoms in these patients.
A study of 305 hospitalized COVID-19 patients showed that approximately two-third of patients with evidence of myocardial injuries had echocardiographic abnormalities. In these patients, risk of in-hospital mortality was increased.
